Preclinical Evaluation
The main goals of preclinical evaluation studies are to determine the safe dose for a first-in-man study and …
Pharmacology
Drug Discovery
The Discovery of a new drug involves an elaborate process. It starts with the synthesis of a large …
Therapeutic Index Pharmacology
Therapeutic Index Pharmacology(TI) is also referred to as the therapeutic ratio. TI is a comparison of the amount …
Dose-Response Relationship
Dose-Response Relationship(DRC), When the relation between drug dose (X-axis) and drug response (Y-axis) is plotted on a linear …
JAK-STAT signalling pathway
Janus kinase (JAK) is a family of intracellular nonreceptor tyrosine kinases which transduce cytokine-mediated signals via the JAK-STAT …
Kinetics of Drug Elimination
Usually, two kinds of elimination kinetics are involved in drug elimination: zero-order and first-order. In zero-order elimination kinetics, …
Enzyme Induction and Inhibition
Enzyme Induction Enzyme induction is a process in which a molecule like a drug induces i.e. initiates or …
Factors Affecting Excretion of Drugs
Drug Excretion When a drug is distributed throughout the body and is getting metabolized, there has to be …
Factors Affecting Drug Metabolism
Drug Metabolism While the drugs are getting distributed in different parts of the body, there are chemical changes …
Factors Affecting Distribution of Drugs
Distribution of Drugs Once a drug is absorbed in the systemic circulation, it can be carried throughout the …